Mimir’s Well-ness offers a unique and comprehensive approach to your healthcare that considers all aspects for your wellness before making evidence based medical recommendations. We work alongside your already established team of providers to help guide them in your care for a more complete and comprehensive diagnostic work-up.

Impactful innovations

Drs Martinez and Harker have recently developed the first ever neonatal circumcision protection device- a functional medical tool which is designed to reduce the risk of injury to infants from accidental slips of both blades and needle during the procedure.

Known as MarkerMesh, this device offers families peace of mind during this routine procedure, in addition to being a relatively inexpensive safety device.

Neuroscientists at the Dagda Laboratory have published exciting data revealing that a new intranasal formulation composed of Forskolin and Noopept is able to reverse Parkinsonian symptoms in rats. The study results were published in the International Journal of Molecular Sciences on the 30th of December. Using a bona fide knock out model rat that faithfully recapitulates Parkinsonian disease (PD) in molecular, physiologic, and motor characteristics, the authors were able to show that this non-invasive formulation significantly reversed motor symptoms, loss of hind limb strength, and neurodegeneration of midbrain dopamine neurons, making them physiologically indistinguishable from wild-type (WT) rats. Standard-of-care for PD consists of oral or intramuscular administration of Levodopa to abrogate motor symptoms by elevating the endogenous level of dopamine in the brain. However, current PD treatment only addresses clinical symptoms of PD without any reversal of degeneration of midbrain dopamine neurons and the cortex. By looking at several key factors, including bio-molecular signaling, neuronal activity, epifluorescence micrographs of brain slices and motor activity, in this exciting study, the authors have shown proof of concept that this intranasal administration is a non-invasive and disease-modifying therapy for the treatment of PD.

Authors: Dr Ruben K Dagda, Mr. Raul Y Dagda, Dr Emmanuel Vazquez-Mayorga, Dr. Bridget Martinez, Ms Aine Gallahue

Mechanoreciprocity refers to a cell’s ability to maintain tensional homeostasis in response to various types of forces. Physical forces are continually being exerted upon cells of various tissue types, even those considered static, such as the brain. Through mechanoreceptors, cells sense and subsequently respond to these stimuli. These forces and their respective cellular responses are prevalent in regulating everything from embryogenic tissue-specific differentiation, programmed cell death, and disease progression, the last of which being the subject of extensive attention. Abnormal mechanical remodeling of cells can provide clues as to the pathological status of tissues.
This becomes particularly important in cancer cells, where cellular stiffness has been recently accepted as a novel biomarker for cancer metastasis. Several studies have also elucidated the importance of cell stiffness in cancer metastasis, with data highlighting that a reversal of tumor stiffness has the capacity to revert the metastatic properties of cancer. In this review, we summarize our current understanding of extracellular matrix (ECM) homeostasis, which plays a prominent role in tissue mechanics. We also describe pathological disruption of the ECM, and the subsequent implications toward cancer and cancer metastasis. In addition, we highlight the most novel approaches toward understanding the mechanisms which generate pathogenic cell stiffness and provide potential new strategies which have the capacity to advance our understanding of one of human-kinds’ most clinically significant medical pathologies. These new strategies include video-based techniques for structural dynamics, which have shown great potential for identifying full-field, high-resolution modal properties, in this case, as a novel application